Winnie's voice was done by Jean Vander Pyl, who is best known for Wilma Flintstone Her other roles include Rosie the Robot in The Jetsons, Marje Huddles and Mrs.Finkerton in Inch Eye, Private Eye. There were no other regular characters in Winnie's segment.
In its second season, the hour-long, two-star show briefly split into two half-hours. Winnie went with Secret Squirrel. Later that same season, the two merged back together. There were 26 episodes altogether. Like a lot of Hanna-Barbera characters, Winnie got a new lease on life as part of an ensemble show, but it took her until 1990. On September 17 of that year, Wake, Rattle & Roll debuted with two cartoon segments — Monster Tails featured all-new characters (pets of classic movie monsters), but Fender Bender 500 featured Winnie, along with Snagglepuss Peter Pottomus, Ricochet Rabbit and several other '60s relics, in a remake of Wacky Races, Vander Pyl reprised her role as Winnie's voice.
Wake, Rattle & Roll didn't last long, and after it folded, Winsome Witch was gone for good.